Monday, February 23, 2015

Review suggests "fully integrative" approach using mulitple models including Drosophila to understand cardiomyopathies

Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L. Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovasc Res. 2015 Jan 18. pii: cvv006. PMID: 25600962.

From the abstract: "Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improvements in screening and detection of gene defects in the human genome as well as a variety of novel animal models (mouse, zebrafish, and drosophila) and in silico computational models. These novel experimental tools have created a platform that is highly complementary to the naturally occurring cardiomyopathies in cats and dogs that had been available for some time. A fully integrative approach, which incorporates all these modalities, is likely required for significant steps forward in understanding the molecular underpinnings and pathogenesis of cardiomyopathies. ..."

Figure 2 of the review summarizes types of heart-related studies that can be done using Drosophila.

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