Thursday, February 5, 2015

Fly model of sleep-related seizures

Lucey BP, Leahy A, Rosas R, Shaw PJ. A New Model to Study Sleep Deprivation-Induced Seizure. Sleep. 2014 Nov 9. pii: sp-00337-14. PMID: 25515102.

From the abstract: "... Sleep deprivation increased seizure susceptibility in adult sesB9ed4/+ and seits1 mutants. Sleep deprivation also increased seizure susceptibility when sesB was disrupted using RNAi. The effect of sleep deprivation on seizure activity was reduced when sesB9ed4/+ flies were given the anti-seizure drug, valproic acid. ... These findings show that Drosophila is a model organism for investigating the relationship between sleep and seizure activity."

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