Ray A, Speese SD, Logan MA. Glial Draper rescues Aβ toxicity in a Drosophila model of Alzheimer's Disease. J Neurosci. 2017 Nov 6. pii: 0862-17. PMID: 29109235.
From the abstract: "Pathological hallmarks of Alzheimer's disease (AD) include amyloid-beta (Aβ) plaques, neurofibrillary tangles, and reactive gliosis. Glial cells offer protection against AD by engulfing extracellular Aβ peptides, but the repertoire of molecules required for glial recognition and destruction of Aβ are still unclear. Here, we show that the highly conserved glial engulfment receptor Draper/MEGF10 provides neuroprotection in an AD model of Drosophila (both sexes). ... Here we show that the glial engulfment receptor Draper is protective in a Drosophila model of AD, reducing levels of amyloid beta (Aβ) peptides, reversing locomotor defects, and extending lifespan. We further show that protein degradation pathways are induced downstream of Draper in AD model flies, supporting a model in which glia engulf and destroy Aβ peptides to reduce amyloid-associated toxicity."