Thursday, May 17, 2018

Review of Drosophila research related to ALS

Zhang K, Coyne AN, Lloyd TE. Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism. Brain Res. 2018 May 9. PMID: 29752901.

From the abstract: " ... The conservation of nervous system biology coupled with the rapid life cycle and powerful genetic tools in the fly have enabled the identification of novel therapeutic targets that have been validated in vertebrate model systems and human patients. A recent example is in the study of the devastating motor neuron degenerative disease amyotrophic lateral sclerosis (ALS). ... In this review, we will discuss the utilization of Drosophila models of ALS with defects in RNA metabolism."

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