Monday, September 30, 2019

Drosophila used in study of receptor for entry into cells of disease-causing viruses

Zhang R, Earnest JT, Kim AS, Winkler ES, Desai P, Adams LJ, Hu G, Bullock C, Gold B, Cherry S, Diamond MS. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Cell Rep. 2019 Sep 3;28(10):2647-2658.e5. doi: 10.1016/j.celrep.2019.07.105. PubMed PMID: 31484075; PubMed Central PMCID: PMC6745702.

From the abstract: "Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. ... Ectopic Mxra8 expression is sufficient to enhance CHIKV infection and lethality in transgenic flies. ... targeting this protein may mitigate disease in humans."

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