Monday, September 30, 2019

Fly model with high uric acid levels established for study of this key risk factor for multiple diseases

Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS Genet. 2019 Aug 15;15(8):e1008318. PubMed PMID: 31415568; PubMed Central PMCID: PMC6695094.

From the abstract: "Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. ... In humans, elevated UA levels resulted from the loss of the of the urate oxidase (Uro) gene ... we established a Drosophila melanogaster model with reduced expression of the orthologous Uro gene to study the pathogenesis arising from elevated UA. Reduced Uro expression in Drosophila resulted in elevated UA levels, accumulation of concretions in the excretory system, and shortening of lifespan ..."

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