Öst A, Lempradl A, Casas E, Weigert M, Tiko T, Deniz M, Pantano L, Boenisch U, Itskov PM, Stoeckius M, Ruf M, Rajewsky N, Reuter G, Iovino N, Ribeiro C, Alenius M, Heyne S, Vavouri T, Pospisilik JA. Paternal diet defines offspring chromatin state and intergenerational obesity. Cell. 2014 Dec 4;159(6):1352-64. PMID: 25480298.
From the abstract: "... We present a Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) and identify genes required for its encoding in offspring. ... Critically, we find evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans. The findings provide insight into the mechanisms underlying intergenerational metabolic reprogramming and carry profound implications for our understanding of phenotypic variation and evolution."
See also: Ozanne SE. Epigenetic signatures of obesity. N Engl J Med. 2015 Mar 5;372(10):973-4. PMID: 25738675.
Tuesday, March 17, 2015
Monday, March 2, 2015
Review of fly models of mitochondrial diseases
Foriel S, Willems P, Smeitink J, Schenck A, Beyrath J. Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics. Int J Biochem Cell Biol. 2015 Feb 7. pii: S1357-2725(15)00034-5. PMID: 25666557.
From the abstract: "... mitochondrial diseases comprise a wide range of clinical, biochemical and genetic heterogeneous disorders. ... Despite intense research efforts, patients are still without effective treatment. ... Here, we review existing Drosophila melanogaster models for mitochondrial diseases, with a focus on alterations in oxidative phosphorylation, and discuss the potential of this powerful model organism in the process of drug target discovery."
From the abstract: "... mitochondrial diseases comprise a wide range of clinical, biochemical and genetic heterogeneous disorders. ... Despite intense research efforts, patients are still without effective treatment. ... Here, we review existing Drosophila melanogaster models for mitochondrial diseases, with a focus on alterations in oxidative phosphorylation, and discuss the potential of this powerful model organism in the process of drug target discovery."
FlyRNAi: Primary cell screen performed at DRSC explores aut...
FlyRNAi: Primary cell screen performed at DRSC explores aut...: Zirin J, Nieuwenhuis J, Samsonova A, Tao R, Perrimon N. Regulators of autophagosome formation in Drosophila muscles. PLoS Genet. 2015 Feb 1...
Drosophila used to help characterize a newly identified mutation in FMRP associated with Fragile X syndrome
Okray Z, de Esch CE, Van Esch H, Devriendt K, Claeys A, Yan J, Verbeeck J, Froyen G, Willemsen R, de Vrij FM, Hassan BA. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol Med. 2015 Feb 17. pii: e201404576. PMID: 25693964.
From the abstract: "... In vivo analyses in Drosophila demonstrate that a patient-mimetic mutation alters the localization and function of Dfmrp in neurons, leading to neomorphic neuronal phenotypes."
From the abstract: "... In vivo analyses in Drosophila demonstrate that a patient-mimetic mutation alters the localization and function of Dfmrp in neurons, leading to neomorphic neuronal phenotypes."
Tuesday, February 24, 2015
Review of fly models of Alzheimer's Disease
Bouleau S, Tricoire H. Drosophila Models of Alzheimer's Disease: Advances, Limits, and Perspectives. J Alzheimers Dis. 2015 Feb 19. PMID: 25697708.
From the abstract: "... The advent of new genome modification technologies should allow the development of more realistic fly models and to better understand the relationship between AD and aging, taking advantage of the fly's short lifespan."
From the abstract: "... The advent of new genome modification technologies should allow the development of more realistic fly models and to better understand the relationship between AD and aging, taking advantage of the fly's short lifespan."
Monday, February 23, 2015
Review suggests "fully integrative" approach using mulitple models including Drosophila to understand cardiomyopathies
Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L. Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovasc Res. 2015 Jan 18. pii: cvv006. PMID: 25600962.
From the abstract: "Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improvements in screening and detection of gene defects in the human genome as well as a variety of novel animal models (mouse, zebrafish, and drosophila) and in silico computational models. These novel experimental tools have created a platform that is highly complementary to the naturally occurring cardiomyopathies in cats and dogs that had been available for some time. A fully integrative approach, which incorporates all these modalities, is likely required for significant steps forward in understanding the molecular underpinnings and pathogenesis of cardiomyopathies. ..."
Figure 2 of the review summarizes types of heart-related studies that can be done using Drosophila.
From the abstract: "Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improvements in screening and detection of gene defects in the human genome as well as a variety of novel animal models (mouse, zebrafish, and drosophila) and in silico computational models. These novel experimental tools have created a platform that is highly complementary to the naturally occurring cardiomyopathies in cats and dogs that had been available for some time. A fully integrative approach, which incorporates all these modalities, is likely required for significant steps forward in understanding the molecular underpinnings and pathogenesis of cardiomyopathies. ..."
Figure 2 of the review summarizes types of heart-related studies that can be done using Drosophila.
Thursday, February 5, 2015
Fly model of sleep-related seizures
Lucey BP, Leahy A, Rosas R, Shaw PJ. A New Model to Study Sleep Deprivation-Induced Seizure. Sleep. 2014 Nov 9. pii: sp-00337-14. PMID: 25515102.
From the abstract: "... Sleep deprivation increased seizure susceptibility in adult sesB9ed4/+ and seits1 mutants. Sleep deprivation also increased seizure susceptibility when sesB was disrupted using RNAi. The effect of sleep deprivation on seizure activity was reduced when sesB9ed4/+ flies were given the anti-seizure drug, valproic acid. ... These findings show that Drosophila is a model organism for investigating the relationship between sleep and seizure activity."
From the abstract: "... Sleep deprivation increased seizure susceptibility in adult sesB9ed4/+ and seits1 mutants. Sleep deprivation also increased seizure susceptibility when sesB was disrupted using RNAi. The effect of sleep deprivation on seizure activity was reduced when sesB9ed4/+ flies were given the anti-seizure drug, valproic acid. ... These findings show that Drosophila is a model organism for investigating the relationship between sleep and seizure activity."
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