Liimatta K, Flaherty E, Ro G, Nguyen DK, Prado C, Purdy AE. A putative acetylation system in Vibrio cholerae modulates virulence in arthropod hosts. Appl Environ Microbiol. 2018 Aug 24. PMID: 30143508.
From the abstract: "Acetylation is a broadly conserved mechanism of covalently modifying the proteome to precisely control protein activity. In bacteria, central metabolic enzymes and regulatory proteins, including those involved in virulence, can be targeted for acetylation. In this study, we directly link a putative acetylation system to metabolite-dependent virulence in the pathogen Vibrio cholerae ... The Drosophila model of Vibrio cholerae infection has revealed that bacterial regulation of acetate and other small metabolites from within the fly gastrointestinal tract is crucial to its virulence. Here, we demonstrate that genes that may modify the proteome of V. cholerae affect virulence towards Drosophila ... These findings further highlight the many layers of regulation that tune bacterial metabolism to alter the trajectory of interactions between bacteria and their hosts."
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