Dourlen P, Chapuis J, Lambert JC. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Curr Genet Med Rep. 2018;6(3):107-115. PMID: 30147999; PMCID: PMC6096908.
From the abstract: "... genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. For Alzheimer's disease (AD), more than 20 risk loci have been identified. However, we are now facing three new challenges: (i) identifying the functional SNP or SNPs in each locus, (ii) identifying the causal gene(s) in each locus, and (iii) understanding these genes' contribution to pathogenesis. ... To address these issues ... a number of high-throughput strategies have been implemented ... Here, we review high-throughput screening, high-content screening, and the use of the Drosophila model (primarily with reference to AD)."
No comments:
Post a Comment