New on the BioRxiv preprint server (not yet peer reviewed):
Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons
Stavroula Petridi, C. Adam Middleton, Alison Fellgett, Laura Covill, Amy Stewart, Jack Munns, Friederike Elisabeth Kohrs, P. Robin Hiesinger, Laurence Wilson, Sangeeta Chawla, Christopher J. H. Elliott
https://www.biorxiv.org/content/10.1101/586073v1
From the Significance Statement: "A key question in Parkinson’s is why dopamine neurons die particularly fast in some parts of the substantia nigra. We focused on the commonest Parkinson’s-related mutation, LRRK2-G2019S. ... Rab10 knock-out rescues G2019S-induced visual and movement degeneration, leaving sleep dysfunction unaffected. ... Rab3 is found in a different subset of dopaminergic neurons and shows no synergy with LRRK2-G2019S. We propose that variations in Rab expression contribute to differences in neurodegeneration ..."
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