Wednesday, April 10, 2019

Review -- fly models of Myotonic Dustrophy Type 1



Souidi A, Zmojdzian M, Jagla K. Dissecting Pathogenetic Mechanisms and Therapeutic Strategies in Drosophila Models of Myotonic Dystrophy Type 1. Int J Mol Sci. 2018 Dec 18;19(12). PMID: 30567354; PMCID: PMC6321436.

From the abstract: "... Here we provide an overview of insights gained from fruit fly DM1 models, either: (i) fundamental with particular focus on newly identified gene deregulations and their link with DM1 symptoms; or (ii) applied via genetic modifiers and drug screens to identify promising therapeutic targets. ..."

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Fig. 1 from Souidi et al. 2018

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