Wednesday, April 30, 2014

Drosophila and the heart--SERCA study

Abraham DM, Wolf MJ. Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. PLoS One. 2013 Oct 3;8(10):e77785. PMID: 24098595; PMCID: PMC3789689.

From the abstract:
"... we show that disruption of CaP60A in a cardiac specific manner results in cardiac dilation and dysfunction ... In addition, the co-expression of a calcium release channel mutation with CaP60A (kum170) is sufficient to rescue the cardiac phenotype but not paralysis. Finally, we show that CaP60A overexpression is able to rescue cardiac function in a model of Drosophila cardiac dysfunction similar to what is observed in mammals ..."

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