Tuesday, April 8, 2014

Review of Drosophila as a model for understanding the genetics and neuropathy of intellectual disability

van der Voet M, Nijhof B, Oortveld MA, Schenck A. Drosophila models of early onset cognitive disorders and their clinical applications. Neurosci Biobehav Rev. 2014 Mar 21. pii: S0149-7634(14)00057-8. PMID: 24661984.

From the abstract:  "... The available resources and efficiency of Drosophila place it in a position to tackle the main challenges in the field: mapping functional modules of ID [intellectual disability] genes to provide conceptually novel insights into the genetic control of cognition, tailored functional studies to improve 'next-generation' diagnostics, and identification of reversible ID phenotypes and medication. ... In conclusion, Drosophila provides many opportunities to advance future medical genomics of early onset cognitive disorders"

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