Thursday, June 12, 2014

Fly study relevant to Parkinson's disease links LRRK2 with Akt, FOXO1 and apoptosis

Chuang CL, Lu YN, Wang HC, Chang HY. Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival. Hum Mol Genet. 2014 Jun 10. PMID: 24916379.

From the abstract: "... Here, we show that LRRK2 protects neurons against apoptosis induced by the Drosophila genes grim, hid and reaper. ... These data establish that LRRK2 can protect neurons from apoptotic insult through a survival pathway in which LRRK2 signals to activate Akt, and then inhibits FOXO1. These results might indicate that a therapeutic pathway to promote neuron survival and to prevent neurodegeneration in Parkinson's disease."

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