Monday, June 2, 2014

Review--Drosophila as a model for development of novel therapeutics to fight infection

Tzelepis I, Kapsetaki SE, Panayidou S, Apidianakis Y. Drosophila melanogaster: a first step and a stepping-stone to anti-infectives. Curr Opin Pharmacol. 2013 Oct;13(5):763-8. PMID: 23992884.

From the abstract: "Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. ... Drug screening in Drosophila offers to fill the gap between in vitro and mammalian model host testing ... alternative screening methods in Drosophila, while low-throughput, may reduce the cost and increase the success rate of preclinical trials."

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