Monday, April 13, 2015

Flies and neurodegeneration--research report on A beta 43 toxicity in flies and review of findings from fly models of tauopathies

Burnouf S, Gorsky MK, Dols J, Grönke S, Partridge L. Aβ(43) is neurotoxic and primes aggregation of Aβ(40) in vivo. Acta Neuropathol. 2015 Apr 11. PMID: 25862636.

From the abstract: "... Besides the well-studied Aβ40 and Aβ42 species, recent data have raised the possibility that Aβ43 peptides might be instrumental in AD pathogenesis, because they are frequently observed in both dense and diffuse amyloid plaques from human AD brains and are highly amyloidogenic in vitro. However, whether Aβ43 is toxic in vivo is currently unclear. Using Drosophila transgenic models of amyloid pathology, we show that Aβ43 peptides are mainly insoluble and highly toxic in vivo ... Altogether, our study demonstrates high pathogenicity of Aβ43 species in vivo and supports the idea that Aβ43 contributes to the pathological events leading to neurodegeneration in AD."

Sun M, Chen L. Studying Tauopathies in Drosophila: A Fruitful Model. Exp Neurol. 2015 Apr 7. pii: S0014-4886(15)00105-3. PMID: 25862286.

From the abstract:
"... summarize key features of transgenic Drosophila models of tauopathies and ... insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models."

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