Wednesday, April 8, 2015

Review highlights contribution of Drosophila research to understanding Parkinson's disease

Vanhauwaert R, Verstreken P. Flies with Parkinson's disease. Exp Neurol. 2015 Feb 20. pii: S0014-4886(15)00043-6. doi: 10.1016/j.expneurol.2015.02.020. PMID: 25708988.

From the abstract: "Parkinson's disease is an incurable neurodegenerative disease. Most cases of the disease are of sporadic origin, but about 10% of the cases are familial. The genes thus far identified in Parkinson's disease are well conserved. Drosophila is ideally suited to study the molecular neuronal cell biology of these genes and the pathogenic mutations in Parkinson's disease. ... fruit flies recapitulate many of the cellular and molecular defects also seen in patients ... Drosophila has played a prominent role in Parkinson's disease research and has provided invaluable insight into the molecular mechanisms of this disease."

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