Thursday, November 19, 2015

Drosophila models of Parkinsons Disease included in study the traditional chinese medicine Tianma Gouteng Yin

Liu LF, Song JX, Lu JH, Huang YY, Zeng Y, Chen LL, Durairajan SS, Han QB, Li M. Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease. Sci Rep. 2015 Nov 18;5:16862. PMID: 26578166.

From the abstract: "Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. ... In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. ..."

No comments:

Post a Comment