Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D. Glial expression of Swiss-cheese (SWS), the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. Dis Model Mech. 2015 Dec 3. PMID: 26634819.
From the abstract: "Swiss-cheese (SWS) and its vertebrate ortholog Neuropathy Target
Esterase (NTE) cause progressive neuronal degeneration in Drosophila and
mice and a complex syndrome in humans that includes mental retardation,
spastic paraplegia, and blindness. SWS and NTE are widely expressed in
neurons but can also be found in glia ... We have used a knockdown approach to specifically address SWS
function in glia ... loss of SWS in pseudocartridge glia causes the formation
of multi-layered glial whorls in the lamina cortex, the first optic
neuropil. This phenotype can be rescued by the expression of SWS and NTE
suggesting that the glial function is conserved in the vertebrate
the loss of SWS in glia impairs neuronal function, thereby playing an
important role in the phenotypes described in the sws mutant. It is
therefore likely that changes in glia also contribute to the pathology
observed in patients that carry mutations in NTE."