Wednesday, December 9, 2015

The holo'ome. Fly and mouse model of colon-microbial interplay in the context of colon cancer

Panagi M, Georgila K, Eliopoulos AG, Apidianakis Y. Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice. Oncotarget. 2015 Dec 4. PMID: 26643871.

From the abstract: "Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at an old age and only in some of the people with the same profile. ... longitudinal multi-omic and personalized studies will help to pinpoint combinations of ... factors ... The intestinal holo'ome - defined as the combination of host and microbiota genomes, transcriptomes, proteomes, and metabolomes - may be imbalanced and shift to disease when the wrong host gene expression profile meets the wrong microbiota composition. ... Detrimental combinations of factors could therefore be pinpointed computationally and validated using animal models, such as mice and flies. ... treatment strategies that break these harmful combinations could be tested in clinical trials. ... we provide an overview of the literature and a roadmap to this end."

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