Panagi M, Georgila K, Eliopoulos AG, Apidianakis Y. Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice. Oncotarget. 2015 Dec 4. PMID: 26643871.
From the abstract: "Specific host genes and intestinal microbes, dysbiosis, aberrant immune
responses and lifestyle may contribute to intestinal inflammation and
cancer, but each of these parameters does not suffice to explain why
sporadic colon cancer develops at an old age and only in some of the
people with the same profile. ... longitudinal
multi-omic and personalized studies will help to pinpoint combinations
of ... factors ... The
intestinal holo'ome - defined as the combination of host and microbiota
genomes, transcriptomes, proteomes, and metabolomes - may be imbalanced
and shift to disease when the wrong host gene expression profile meets
the wrong microbiota composition. ... Detrimental combinations of factors could
therefore be pinpointed computationally and validated using animal
models, such as mice and flies. ... treatment strategies that break
these harmful combinations could be tested in clinical trials. ...
we provide an overview of the literature and a roadmap to this end."