Schweizer Burguete A, Almeida S, Gao FB, Kalb R, Akins MR, Bonini NM. GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function. Elife. 2015 Dec 9;4. PMID: 26650351.
From the abstract: "Microsatellite expansions are the leading cause of numerous
neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG
microsatellite repeat RNAs associated with C9orf72 in ALS/FTD and
with polyglutamine diseases, respectively, localize to neuritic
granules that undergo active transport into distal neuritic segments. ... Using a Drosophila GGGGCC expansion disease model, we
characterize dendritic branching defects that are modulated by FMRP and
Orb2. ... These data suggest that expanded repeat RNAs
interact with the mRNA transport and translation machinery, causing
transport granule dysfunction. This could be a novel mechanism
contributing to the neuronal defects associated with C9orf72 and other microsatellite expansion diseases."