Wednesday, October 26, 2016

Green-glowing flies used in study relevant to Huntington's disease

Babcock DT, Ganetzky B. Transcellular spreading of huntingtin aggregates in the Drosophila brain. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):E5427-33. PMID: 26351672; PMCID: PMC4593132.

From the abstract: "A key feature of many neurodegenerative diseases is the accumulation and subsequent aggregation of misfolded proteins. Recent studies have highlighted the transcellular propagation of protein aggregates in several major neurodegenerative diseases, although the precise mechanisms underlying this spreading and how it relates to disease pathology remain unclear. Here we use a polyglutamine-expanded form of human huntingtin (Htt) with a fluorescent tag to monitor the spreading of aggregates in the Drosophila brain in a model of Huntington's disease. ... We show that Htt aggregates cause non-cell-autonomous pathology ..."

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