Siddique YH, Naz F, Jyoti S, Ali F, Rahul. Effect of Genistein on the Transgenic Drosophila Model of Parkinson's Disease. J Diet Suppl. 2018 Jul 3:1-14. PMID: 29969325.
From the abstract: "Parkinson's disease (PD) is the second-most common neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. ... PD flies were exposed to 10, 20, 30, and 40 µM of genistein (mixed in diet) for 24 days. A significant dose-dependent increase in the life span and delay in the loss of climbing ability were observed in the PD flies exposed to genistein (p < .05). A significant dose-dependent decrease in oxidative stress markers and increase in dopamine content were observed in PD flies exposed to genistein. However, the exposure of genistein did not inhibit the expression of α-synuclein in the brains of PD flies."