Monday, July 9, 2018

Investigation of the effects of green tea on a fly model of Huntington's Disease

Varga J, Dér NP, Zsindely N, Bodai L. Green tea infusion alleviates neurodegeneration induced by mutant Huntingtin in Drosophila. Nutr Neurosci. 2018 Jul 4:1-7. PMID: 29973113.

From the abstract: "Green tea infusion contains a complex mixture of polyphenolic compounds that were shown to provide health benefits. It was previously demonstrated that (-)-epigallocatechin-3-gallate, ... present in green tea, has a suppressing effect on various aspects of pathogenesis in models of Huntington's disease (HD) ... In this study, we aimed to investigate, whether green tea infusion prepared as for human consumption has similar positive effects. ... We used a transgenic Drosophila model of HD to study the effects of green tea on mutant Huntingtin induced phenotypes. ... We found that green tea supplementation reduced mutant Huntingtin induced neurodegeneration in Drosophila and positively impacted the longevity of mutant Huntingtin expressing flies. However, green tea did not rescue reduced viability of Drosophila expressing mutant Huntingtin or increased longevity of wild-type fruit flies. ... Our results indicate that green tea consumption might have a modest positive effect on symptoms of HD."

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