Zhu ZJ, Wu KC, Qian ZM, Yung WH, Ke Y. Drosophila models for studying iron-related neurodegenerative diseases. Sheng Li Xue Bao. 2014 Feb 25;66(1):47-54. PMID: 24553869.
From the abstract: "In recent years, iron has been regarded as a common pathological feature of many neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Friedreich's ataxia (FRDA). ... characteristics ... turn Drosophila into an excellent in vivo genetic system for screening iron-related modifiers in different neurodegenerative conditions ... "
Thursday, May 28, 2015
Review looks at fly and mouse models of Fragile X syndrome
Santos AR, Kanellopoulos AK, Bagni C. Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us. Learn Mem. 2014 Sep 16;21(10):543-55. PMID: 25227249; PMCID: PMC4175497.
From the abstract: "... Here, we review to which extent these biological models are affected by the absence of FMRP, pointing out the similarities with the observed human dysfunction. Additionally, we discuss several potential treatments under study in animal models that are able to partially revert some of the FXS abnormalities. "
From the abstract: "... Here, we review to which extent these biological models are affected by the absence of FMRP, pointing out the similarities with the observed human dysfunction. Additionally, we discuss several potential treatments under study in animal models that are able to partially revert some of the FXS abnormalities. "
Fly study related to ALS points to possible new direction for therapeutic development
Chang JC, Hazelett DJ, Stewart JA, Morton DB. Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS. Brain Res. 2014 Oct 10;1584:39-51. PMID: 24275199; PMCID: PMC4031311.
From the abstract: "Dysfunction of the RNA-binding protein, TDP-43, is strongly implicated as a causative event in many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). ... Using Drosophila melanogaster to model TDP-43 loss of function, we show that reduced levels of the voltage-gated calcium channel, cacophony, mediate some of the physiological effects of TDP-43 loss. ... Restoring the levels of cacophony in all neurons or selectively in motor neurons rescued these locomotion defects. ... If similar effects of cacophony or related calcium channels are found in human ALS patients, these could be targets for the development of pharmacological therapies for ALS."
From the abstract: "Dysfunction of the RNA-binding protein, TDP-43, is strongly implicated as a causative event in many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). ... Using Drosophila melanogaster to model TDP-43 loss of function, we show that reduced levels of the voltage-gated calcium channel, cacophony, mediate some of the physiological effects of TDP-43 loss. ... Restoring the levels of cacophony in all neurons or selectively in motor neurons rescued these locomotion defects. ... If similar effects of cacophony or related calcium channels are found in human ALS patients, these could be targets for the development of pharmacological therapies for ALS."
Wednesday, May 27, 2015
FlyRNAi: in vivo RNAi screen for "flyabetes" phenotype reve...
FlyRNAi: in vivo RNAi screen for "flyabetes" phenotype reve...: Ugrankar R, Berglund E, Akdemir F, Tran C, Kim MS, Noh J, Schneider R, Ebert B, Graff JM. Drosophila glucome screening identifies Ck1alpha a...
Tuesday, May 26, 2015
FlyRNAi: IMP integrative tool for functional genomics updat...
FlyRNAi: IMP integrative tool for functional genomics updat...: Wong AK, Krishnan A, Yao V, Tadych A, Troyanskaya OG. IMP 2.0: a multi-species functional genomics portal for integration, visualization and...
Fly model links zinc to kidney stones, opening possible new routes to prevention and treatment
Chi T, Kim MS, Lang S, Bose N, Kahn A, Flechner L, Blaschko SD, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Mandel N, Miller J, Ramanathan A, Killilea DW, Brückner K, Kapahi P, Stoller ML. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS One. 2015 May 13;10(5):e0124150. PMID: 25970330; PMCID: PMC4430225.
From the abstract: "... Our findings open a novel perspective on the etiology of urinary stones and related diseases, which may lead to the identification of new preventive and therapeutic approaches."
From the abstract: "... Our findings open a novel perspective on the etiology of urinary stones and related diseases, which may lead to the identification of new preventive and therapeutic approaches."
Review includes contribution of model systems to understanding lipodystrophies and dyslipidemias
Prieur X, Le May C, Magré J, Cariou B. Congenital lipodystrophies and dyslipidemias. Curr Atheroscler Rep. 2014 Sep;16(9):437. PMID: 25047893.
From the abstract: "... The precise mechanisms by which the lack of adipose tissue causes dyslipidemia remain largely unknown. In recent years, new insights have arisen from data obtained in vitro in adipocytes, yeast, drosophila, and very recently in several genetically modified mouse models of generalized lipodystrophy. ..."
From the abstract: "... The precise mechanisms by which the lack of adipose tissue causes dyslipidemia remain largely unknown. In recent years, new insights have arisen from data obtained in vitro in adipocytes, yeast, drosophila, and very recently in several genetically modified mouse models of generalized lipodystrophy. ..."
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