Thursday, December 20, 2012

iMAD approach to host-pathogen interaction detection. Recent report.

These authors report a strategy for simultaneous genetic manipulation of the host cell model (Drosophila cells) and pathogen genes (Legionella pneumophila) to identify interactions.

O'Connor TJ, Boyd D, Dorer MS, Isberg RR. Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science. 2012 Dec 14;338(6113):1440-4. doi: 10.1126/science.1229556. PubMed PMID: 23239729.

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