Friday, November 14, 2014

Fly model of Alzheimer's disease--Finding what's not?

Lüchtenborg AM, Katanaev VL. Lack of evidence of the interaction of the Aß peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease. Mol Brain. 2014 Nov 12;7(1):81. PMID: 25387847.

From the abstract: "... Our data confirm that the life span is a useful readout of Aß42 induced neurotoxicity in Drosophila; the neuromuscular junction seems however not to be an appropriate model to study AD in flies. Additionally, our results challenge the hypothesis that Wnt signaling might be implicated in Aß42 toxicity and might serve as a drug target against AD."

No comments:

Post a Comment