Tuesday, November 11, 2014

Review--Myosin in model systems and links to disease

Lee CF, Melkani GC, Bernstein SI. The UNC-45 Myosin Chaperone: From Worms to Flies to Vertebrates. Int Rev Cell Mol Biol. 2014;313:103-44. PMID: 25376491.

From the abstract: "UNC-45 (uncoordinated mutant number 45) is a UCS (UNC-45, CRO1, She4p) domain protein that is critical for myosin stability and function. It likely aides in folding myosin during cellular differentiation and maintenance, and protects myosin from denaturation during stress. ... we provide insights into UNC-45 functions, its potential mechanism of action, and its roles in human disease."

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