Wednesday, November 12, 2014

Review--neurotransmitter release in mammals and flies--relevance to neurodegenerative disease

Davis GW, Müller M. Homeostatic Control of Presynaptic Neurotransmitter Release. Annu Rev Physiol. 2014 Nov 5. PMID: 25386989.

From the abstract: "This review focuses on the homeostatic modulation of presynaptic neurotransmitter release ... we highlight criteria that can be used to define a process as being under homeostatic control. Next, we review the remarkable conservation of presynaptic homeostasis at the Drosophila, mouse, and human neuromuscular junctions ... We then highlight recent progress identifying cellular and molecular mechanisms. We conclude by reviewing emerging parallels between the mechanisms of homeostatic signaling and genetic links to neurological disease."

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