Tuesday, May 12, 2015

Review -- fly models and Parkinson's disease

West RJ, Furmston R, Williams CA, Elliott CJ. Neurophysiology of Drosophila models of Parkinson's disease. Parkinsons Dis. 2015;2015:381281. PMID: 25960916.

The authors outline several pluses of the fly system, including stating that  "... Drosophila models are instrumental in exploring the mechanisms of neurodegeneration, with several PD-related mutations eliciting related phenotypes including sensitivity to energy supply and vesicular deformities. These are leading to the identification of plausible cellular mechanisms, which may be specific to (dopaminergic) neurons and synapses rather than general cellular phenotypes. ..."

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