Wednesday, June 3, 2015

New fly model related to Adult T-cell leukemia/lymphoma (ATLL)

Shirinian M, Kambris Z, Hamadeh L, Grabbe C, Journo C, Mahieux R, Bazarbachi A. A transgenic Drosophila melanogaster model to study Human T-Lymphotropic Virus oncoprotein Tax-1-driven transformation in vivo. J Virol. 2015 May 20. pii: JVI.00918-15. PMID: 25995252.

From the abstract: "HTLV-1-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. ... We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. ... Tax-1 but not Tax-2 induces ommatidia perturbation and increased plasmatocyte proliferation ... validating this new in vivo model."

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