Monday, June 15, 2015

Studies use multiple fly models to investigate links between iron and A-beta

Ott S, Dziadulewicz N, Crowther DC. Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms. Dis Model Mech. 2015 Apr 23. pii: dmm.019042. PMID: 26035384.

From the abstract: "Metals including iron are present at high concentrations in amyloid plaques in patients with Alzheimer's disease where they are also thought to be co-factors in generating oxidative stress and modulating amyloid formation. In this study we present data from several Drosophila models of neurodegenerative proteinopathies indicating that the interaction between iron and Aβ is specific and is not seen for other aggregation-prone polypeptides. ... Understanding how Aβ mediates neurotoxic effects in vivo will help us better target pathological pathways using aggregation-blockers and metal-modifying agents."

No comments:

Post a Comment