Friday, July 17, 2015

Huntington's disease-related study includes work in flies--specific HTT cleavages related to toxicity

El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F. Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. EMBO J. 2015 Jul 12. pii: e201490808. PMID: 26165689.

From the abstract: "... we show that specific cleavages are required to disrupt intramolecular interactions within HTT and to cause toxicity in cells and flies ..."

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