Monday, July 27, 2015

"At a glance" review and poster summarize results from fly and other models regarding retromer complex

Wang S, Bellen HJ. The retromer complex in development and disease. Development. 2015 Jul 15;142(14):2392-6. PMID: 26199408.

From the abstract: "The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. ... a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retromer function in vivo. "

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