Wednesday, July 22, 2015

Methods chapter reviews fly as model for spetraplakin-related diseases

Hahn I, Ronshaugen M, Sánchez-Soriano N, Prokop A. Functional and genetic analysis of spectraplakins in Drosophila. In: Intermediate filament associated proteins. Methods in enzymology: Elsevier; 2015. p. in press. Corrected proof is available through the authors' institutional site.

From the abstract: "The cytoskeleton is a dynamic network of filamentous protein polymers required for virtually all cellular processes. ... One unique class of proteins, the spectraplakins, bind, regulate, and integrate the functions of ... three classes of cytoskeleton proteins. ... They have OMIM-listed disease links to epidermolysis bullosa and hereditary sensory and autonomic neuropathy (HSAN). ... To study the broad range of functions and complexity of these proteins, Drosophila is a powerful model. ... Here we use the example of Shot to illustrate how the various tools and strategies available for Drosophila can be employed to decipher and dissect cellular roles and molecular mechanisms of spectraplakins."

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