Wednesday, August 19, 2015

New fly model of ALS -- temporarl and spatial control of TDP-43 expression

Cheng CW, Lin MJ, Shen CJ. Rapamycin Alleviates Pathogenesis of a New Drosophila Model of ALS-TDP. J Neurogenet. 2015 Jul 29:1-47. PMID: 26219309.

From the abstract: "... We describe the generation and characterization of a new fly model of ALS-TDP with transgenic expression of the Drosophila ortholog of TDP-43, dTDP, in adult flies under the control of a temperature sensitive motor neuron-specific GAL4, thus bypassing the deleterious effect of dTDP during development. ... In sum, this Drosophila model of ALS-TDP under temporal and spatial control presents a useful new genetic tool for the screening and validation of therapeutic drugs for ALS. Furthermore, the data support our previous finding that autophagy activators including rapamycin are potential therapeutic drugs for the progression of neurodegenerative diseases with TDP-43 proteinopathies."

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