Friday, August 21, 2015

Review--Drosophila research contribution to understaning polyQ diseases

Xu Z, Tito A, Rui YN, Zhang S. Studying Polyglutamine Diseases in Drosophila. Exp Neurol. 2015 Aug 6. pii: S0014-4886(15)30063-7. PMID: 26257024.

From the abstract: "Polyglutamine (polyQ) diseases are a family of dominantly transmitted neurodegenerative disorders caused by an abnormal expansion of CAG trinucleotide repeats in the protein-coding regions of the respective disease-causing genes. ... Over the past two decades, Drosophila has proven to be successful in modeling this family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as ... neuronal degeneration. Additionally, it has been valuable in probing the pathogenic mechanisms, in identifying and evaluating disease modifiers, and in helping elucidate the normal functions of disease-causing genes. Knowledge learned from this simple invertebrate organism has had a large impact on our understanding of these devastating brain diseases."

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