Friday, August 21, 2015

Review--flies and prion disease

Bujdoso R, Landgraf M, Jackson WS, Thackray AM. Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. World J Virol. 2015 Aug 12;4(3):188-97. PMID:
26279981; PMCID: PMC4534811.

From the abstract: "Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer's disease, Huntington's disease, Parkinson's disease, motor neuron disease, tauopathies and prion diseases. ... Prion diseases are an important paradigm for neurodegenerative conditions in general ... Here we review the role of cell cycle activity and the DNA damage response in neurodegeneration associated with protein misfolding diseases ... In doing so, we highlight PrP transgenic Drosophila as a tractable model for the genetic analysis of transmissible mammalian prion disease."

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