van der Voet M, Nijhof B, Oortveld MA, Schenck A. Drosophila models of early onset cognitive disorders and their clinical applications. Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:326-42. PMID: 24661984.
From the abstract: "... For the extremely large, genetically and
phenotypically heterogeneous group of intellectual disability (ID)
disorders, more than 600 causative genes have been identified to date.
However, knowledge about the molecular mechanisms and networks disrupted
by these genetic aberrations is lagging behind. The fruit fly
Drosophila has emerged as a powerful model organism to close this
knowledge gap. This review summarizes recent achievements that have been
made in this model and envisions its future contribution to our
understanding of ID genetics and neuropathology. ... In conclusion, Drosophila provides many opportunities to
advance future medical genomics of early onset cognitive disorders."