Monday, October 5, 2015

A 'how-to' review--small molecule screens with fly models of neurological disorders

Poidevin M, Zhang F, Jin P. Small-molecule screening using Drosophila models of human neurological disorders. Methods Mol Biol. 2015;1263:127-38. PMID: 25618341.

From the abstract:
“… Drosophila has emerged as a premiere model system for the study of human neurodegenerative diseases, due to the realization that flies and humans share many structurally and functionally related gene families. ... Here, we describe how to utilize the existing fruit fly models of human neurological disorders to identify small-molecule leads that could potentially be further developed for therapeutic use.”

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