Friday, October 30, 2015

New fly model of Parkinson's disease--alteration of the fly PGC-1alpha ortholog, spargel (srl)

Merzetti EM, Staveley BE. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster. Free online in BMC Neurosci. 2015 Oct 26;16(1):70. PMID: 26502946; PMCID: PMC4623274.

From the abstract: "... Directed expression of [RNAi against the Drosophila PGC-1alpha ortholog spargel (srl)] in the D. melanogaster eye causes abnormal ommatidia and bristle formation ... Ddc-Gal4 mediated tissue specific expression of srl transgene constructs in D. melanogaster DA neurons causes altered lifespan and climbing ability. Expression of a srl-RNAi causes an increase in mean lifespan but a decrease in overall loco-motor ability while induced expression of srl-EY causes a severe decrease in mean lifespan and a decrease in loco-motor ability ... The reduced lifespan and climbing ability associated with a tissue specific expression of srl in DA neurons provides a new model of PD in D. melanogaster ..."

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