Merzetti EM, Staveley BE. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster. Free online in BMC Neurosci. 2015 Oct 26;16(1):70. PMID: 26502946; PMCID: PMC4623274.
From the abstract: "... Directed
expression of [RNAi against the Drosophila PGC-1alpha ortholog spargel (srl)] in the D. melanogaster eye causes abnormal
ommatidia and bristle formation ... Ddc-Gal4 mediated tissue specific
expression of srl transgene constructs in D. melanogaster DA neurons
causes altered lifespan and climbing ability. Expression of a srl-RNAi
causes an increase in mean lifespan but a decrease in overall loco-motor
ability while induced expression of srl-EY causes a severe decrease in
mean lifespan and a decrease in loco-motor ability ... The
reduced lifespan and climbing ability associated with a tissue specific
expression of srl in DA neurons provides a new model of PD in D.