Monday, February 15, 2016

Huntingtin protein as a scaffold for macroautophagy

Rui YN, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S. Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar;17(3):262-75. PMID: 25686248; PMCID: PMC4344873.

From the abstract: "Selective macroautophagy is an important protective mechanism against diverse cellular stresses. ... Here, we demonstrate that Huntingtin, the Huntington disease gene product, functions as a scaffold protein for selective macroautophagy but it is dispensable for non-selective macroautophagy. In Drosophila, Huntingtin genetically interacts with autophagy pathway components. In mammalian cells, Huntingtin physically interacts with the autophagy cargo receptor p62 to facilitate its association with the integral autophagosome component LC3 and with Lys-63-linked ubiquitin-modified substrates. ... Our data uncover an important physiological function of Huntingtin and provide a missing link in the activation of selective macroautophagy in metazoans."

See also comment in:
Gelman A, Rawet-Slobodkin M, Elazar Z. Huntingtin facilitates selective autophagy. Nat Cell Biol. 2015 Mar;17(3):214-5. PMID: 25720962.

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