Kooij V, Venkatraman V, Tra J, Kirk JA, Rowell J, Blice-Baum A, Cammarato A, Van Eyk JE. Sizing up models of heart failure: Proteomics from flies to humans. Proteomics Clin Appl. 2014 Oct;8(9-10):653-64. PMID: 24723306; PMCID: PMC4282793.
From the abstract: "Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome... The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable ... Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets ... In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated."