Monday, February 15, 2016

Review discusses fly as model for studying chromatin factors relevant to intellectual disability

Looks like a nice starting point or resource for someone interested to use the fly to study chromatin regulators and neurological diseases.

Taniguchi H, Moore AW. Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and neuropsychiatric disorder models. Bioessays. 2014 Sep;36(9):872-83. PMID: 25067789.

From the abstract:  "Disruptions in chromatin regulator genes are frequently the cause of neurodevelopmental and neuropsychiatric disorders. ... Using Drosophila allows targeted manipulation of chromatin regulators in defined neuronal classes, lineages, or circuits, revealing their roles in neuronal precursor self-renewal, dendrite and axon targeting, neuron diversification, and the tuning of developmental signaling pathways. ..."

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