This paper describes a molecular characterization of the Drosophila ortholog of human TP53 (p53), a gene commonly associated with cancer. The authors report that fly and human p53 proteins "generally showed a similar energetic and functional response to cancer associated mutations."
Herzog G, Joerger AC, Shmueli MD, Fersht AR, Gazit E, Segal D. Evaluating Drosophila p53 as a model system for studying cancer mutations. J Biol Chem. 2012 Nov 7. PubMed PMID: 23135266.
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