Six restless legs. New fly model. Breaking report.

These authors describe a "reverse genetic analysis of a ... poorly understood gene ... and the development of an RLS animal model that closely recapitulates all disease phenotypes." 

An alignment of human BTBD9 and fly CG1826 (a.k.a BTBD9) from DIOPT is shown on the right. Click the image to enlarge.

Freeman A, Pranski E, Miller RD, Radmard S, Bernhard D, Jinnah HA, Betarbet R, Rye DB, Sanyal S. Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome. Curr Biol. 2012 Jun 19;22(12):1142-8. doi:10.1016/j.cub.2012.04.027. PubMed PMID: 22658601; PubMed Central PMCID: PMC3381864.

Shaw PJ, Duntley SP. Neurological disorders: towards a mechanistic understanding of restless legs syndrome. Curr Biol. 2012 Jun 19;22(12):R485-6. doi: 10.1016/j.cub.2012.05.004. PubMed PMID: 22720681.

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Genome-wide association study (GWAS) reports include this one in the open access journal PLoS Genetics.