Herteleer L, Zwarts L, Hens K, Forero D, Del-Favero J, Callaerts P. Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila. Psychopharmacology (Berl). 2016 May;233(9):1751-62. PMID: 26852229.
From the abstract: "Lithium and valproate (VPA) are drugs used in the management of bipolar disorder. ... We used Drosophila culture cells and adult flies to analyze the transcriptional effects of lithium and VPA and define mechanistic pathways. ... Transcriptional profiles were determined for Drosophila S2-cells and adult fly heads following lithium or VPA treatment. ... Lithium and VPA act on evolutionarily conserved pathways in Drosophila and mammalian models."