Thursday, December 15, 2016

Review in the journal Traffic on neuronal growth factor signaling -- relevance to ALS and hereditary spastic paraplegia

Deshpande M, Rodal AA. The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila. Traffic. 2016 Feb;17(2):87-101. PMID: 26538429.

From the abstract: "... Neuronal growth factor signaling is highly dependent on membrane traffic... Here, we review recent findings from the Drosophila larval neuromuscular junction (NMJ) that illustrate how specific steps of intracellular traffic and inter-organelle interactions impinge on signaling ... These membrane trafficking and signaling pathways have been implicated in human motor neuron diseases including amyotrophic lateral sclerosis and hereditary spastic paraplegia, highlighting their importance for neuronal health and survival."

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