Thursday, December 15, 2016

Fly as model for studying the effect of maternal diet or obesity on offspring

Brookheart RT, Duncan JG. Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity. Mol Cell Endocrinol. 2016 Nov 5;435:20-8. PMID: 26687062; PMCID: PMC4903087.

From the abstract: "... Several studies in humans and rodents demonstrate a correlation between the risks of maternal overnutrition and factors such as epigenetics, mitochondrial dysfunction, insulin resistance, ER stress, and immune system disruption. At present, the molecular mechanisms connecting these factors to maternal obesity are unknown. This review focuses on the use of Drosophila melanogaster to study human metabolic diseases, including obesity, and its emerging use to elucidate the mechanisms of maternal overnutrition and the impact on offspring."

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