Friday, December 16, 2016

Review of Drosophila and other invertebrate models of Tauopathies

Hannan SB, Dräger NM, Rasse TM, Voigt A, Jahn TR. Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models. J Neurochem. 2016 Apr;137(1):12-25. PMID: 26756400.

From the abstract: "Abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by Alzheimer's disease (AD) ... An important discovery came with the demonstration that over-expression of human tau in Drosophila leads to premature mortality and neuronal dysfunction including neurodegeneration, recapitulating some key neuropathological features of the human disease. ... We discuss the utility and application of invertebrate models in elucidating the cellular and molecular functions of novel and uncharacterized disease modifiers identified in large-scale screens as well as for investigating the function of genes identified as risk factors in genome-wide association studies from human patients in the post-genomic era. ..."

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